Science

Dedicated to finding a cure for ALS.

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Every dollar raised through Augie’s Quest to Cure ALS is dedicated to driving the innovative science happening at the ALS Therapy Development Institute (ALS TDI). While we are laser focused on curing ALS, we hope our research leads to medical advancements for all neurodegenerative diseases.

What is ALS?

Disease

Amyotrophic lateral sclerosis, or ALS, is a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement.

Diagnosis

There is no single diagnostic test for ALS. However, experts in the disease, usually neurologists specializing in neuromuscular diseases, are very capable of diagnosing it. There are, on average, 15 people diagnosed with ALS every day, and roughly 30,000 people in America have this condition.

Prognosis

Most people with ALS live 2-5 years after their first signs of disease. About 10% of people with ALS survive at least 10 years. This variable rate of disease progression makes prognosis difficult to predict and therapies challenging to develop.

ABOUT ALS TDI

The ALS Therapy Development Institute is dedicated to finding a cure for ALS.  Our innovative science and cutting edge approach have resulted in a promising treatment for ALS.  We also pioneered the ALS Precision Medicine Program, the world’s premier program and partnership with ALS patients to discover additional potential treatments.

MISSION

The ALS Therapy Development Institute and its scientists actively discover and develop treatments for ALS.  We are the world’s first and largest nonprofit biotech focused 100 percent on ALS research.  Led by people with ALS and drug development experts, we understand the urgent need to slow and stop this disease.

Results

As the world’s first and largest nonprofit biotech focused 100 percent on ALS, ALS TDI’s innovative science and cutting edge approach have resulted in:

  • The identification of a promising treatment for ALS: AT-1501
  • The largest database of preclinical drug studies in animal models of ALS, with more being screened each year
  • The world’s first Precision Medicine Program that has led to findings that may speed up drug discovery and therapeutic development for ALS
  • The largest database integrating ALS genetics, voice recordings, lifestyle, demographics, and accelerometer data that has resulted in the identification of algorithms and tools that may speed up all ALS clinical research
  • The most preclinical validations of proposed treatments for ALS in clinical development or clinical trials today
Learn more about our

RESEARCH

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Finding a Cure

Finding a Cure

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