ALS is not incurable – only underfunded.
Augie’s Quest to Cure ALS raises the funds and awareness urgently needed to advance cutting-edge research, fast-track effective treatments, and ultimately, find a cure for ALS.
Fast-Tracking the Most Promising ALS Treatment Yet
“I’m excited and hopeful about AT-1501 as a potential treatment for people living with ALS,” said Augie Nieto, Chairman and Co-Founder of Augie’s Quest to Cure ALS.
Novus Therapeutics announced in November 2020 that the first subject has been enrolled in the Phase 2a clinical trial evaluating AT-1501 in adults with amyotrophic lateral sclerosis (ALS). AT-1501 blocks the activation of the CD40L pathway, which has been shown to improve muscle function, slow disease progression, and improve survival in a pre-clinical animal model of ALS.
David-Alexandre C. Gros, MD, CEO of Novus Therapeutics tweeted: “There would be no AT-1501 without Augie & Lynne Nieto, Augie’s Quest, and the ALS Development Institute. Novus Therapeutics is excited and proud to build on their extraordinary accomplishments and to continue working together to develop better treatment options for people living with ALS.”
This marks the very first time a non-profit organization has ever reached this stage of drug development – in any disease indication.
It is likely our findings and treatment discoveries for ALS may also help fight other neurodegenerative diseases in the future. The development of AT-1501 may also have a significant impact in Type 1 Diabetes and Alzheimer’s disease as well as many autoimmune diseases including Lupus, Sjogren’s syndrome, psoriasis, and rheumatoid arthritis.
“It’s really incredible. For 15 years, Augie’s Quest has been dedicated to raising the critical funds and broad awareness needed to help fast-track ALS TDI’s cutting-edge ALS research – specifically providing ALS TDI with more than $150 million to advance its efforts to end ALS,” commented Steven Perrin Ph.D., CEO of ALS TDI.
Augie’s Quest Translational Research Center at ALS TDI
In January 2020, the ALS Therapy Development Institute announced the Augie’s Quest Translational Research Center at ALS TDI. This Research Center honors the work, innovation and steadfast support of Augie’s Quest and its many generous and committed donors to finding a cure for ALS. Housed within ALS TDI’s laboratory, the Augie’s Quest Translational Research Center will help to strengthen its existing and future research efforts by aiming to dissect mechanisms of clinical ALS and use the knowledge to develop new, more powerful drug discovery platforms and facilitate more effective drug development in ALS.
“We owe much of our progress and ability to expand this transformative, essential research to Augie’s Quest. And, we are honored to celebrate this impact on our science,” says Fernando Vieira, M.D., Chief Scientific Officer, ALS Therapy Development Institute.
Precision Medicine Program (PMP):
ALS TDI’s translational research effort was initiated and is carried on in tight integration with its Precision Medicine Program (PMP), the most comprehensive and longest running translational research study in ALS. Through the PMP, researchers at ALS TDI partner with people with ALS around the world to share data that feeds into the Augie’s Quest Translational Research Center. This integration serves our mission to discover and develop effective treatments for ALS.
The PMP uses big data to better understand ALS progression on a patient-by-patient basis, and provides people with ALS personalized information to guide their individual ALS journey. Combing through these large datasets that trace and define a person’s unique experience with ALS helps accelerate our science to potentially streamline the clinical trial process, making it more agile and less expensive. We believe the next ALS breakthroughs will come from this robust program!
We are working day in and out to bring the next promising ALS treatments successfully through to clinical trials, and as quickly as possible.
One big reason we’re in this position today – is our innovative model. It’s driven by the business savvy of Augie Nieto and our board, combined with our collective, unlimited passion and vision to end ALS. We are certain one day we’ll go from saying “Lou Gehrig’s disease” to “Augie’s Cure.”
There will never be a single, magic silver bullet to treat and cure ALS. We know ALS is very complex, and each person’s ALS is unique, progressing and presenting differently. We will need multiple treatment options to support the ALS community and give every person with ALS a fighting chance against this disease.
What is ALS?
Amyotrophic lateral sclerosis, or ALS, is a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement.
There is no single diagnostic test for ALS. However, experts in the disease, usually neurologists specializing in neuromuscular diseases, are very capable of diagnosing it. There are, on average, 15 people diagnosed with ALS every day, and roughly 30,000 people in America have this condition.
Most people with ALS live 2-5 years after their first signs of disease. About 10% of people with ALS survive at least 10 years. This variable rate of disease progression makes prognosis difficult to predict and therapies challenging to develop.